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ITGA7 Rat anti-Mouse, Clone: 334908, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA524065

Catalog No. PIMA524065


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Description

Description

Reactivity with other Integrin alpha 7 isoforms was not tested. In direct ELISAs, no cross-reactivity with recombit mouse Integrin alpha 2, alpha 3, alpha 4, alpha 5, alpha 9, alpha E, alpha X, recombit human Integrin alpha L, or alpha 11 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Integrins are heterodimers composed of noncovalently associated transmembrane alpha and beta subunits. The 16 alpha and 8 beta subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors, both receptor clustering and ligand occupancy are necessary for the activation of integrinmediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Specifications

Specifications

ITGA7
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q61738
Integrin alpha-7, Integrin alpha-7 light chain, Integrin alpha-7 70 kDa form, ITGA7, UNQ406/PRO768
Rat
IgG2B
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
16404
Flow Cytometry
334908
Unconjugated
Itga7
Lyophilized
ITGA7
CHO-derived recombit mouse Integrin alpha 7 Phe34-Pro1036
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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