CD18, APC, clone: 212701, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523529
CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.In direct ELISAs, no cross-reactivity with recombinant human Integrin beta 1 or recombinant mouse Integrin alpha 5 is observed.
|Mouse myeloma cell line NS0-derived recombinant human Integrin beta 2/CD18 Gln23-Asn700|
|Buffered saline solution with BSA and 0.09% sodium azide|
|Cd18, LAD, LCAMB, Lfa1, MF17, Integrin beta-2 subunit, ITGB2, cluster designation 18|
|Store at 4°C, store in the dark, do not freeze|
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