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CD61 Mouse anti-Human, FITC, Clone: 43.PL, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112148

Catalog No. 01-670-867


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Description

Description

CD61 recognizes an Mr 110-kdalton (kDa) protein, also known as gpIIIa, the common ßsubunit (integrin ß3-chain) of the gpIIb/IIIa complex and the vitronectin receptor (VNR). The gpIIb/IIIa complex and the VNR are integrins, ie, a/b-heterodimeric glycoprotein complexes that are involved in cell adhesion. With the CD41 antigen (gpIIb or aIIb), the CD61 antigen forms the gpIIb/IIIa complex, which acts as a receptor for fibrinogen, von Willebrand factor (vWf), fibronectin and vitronectin on activated platelets. With the CD51 antigen (VNR a-chain or av), the CD61 antigen forms the VNR, which mediates activation-independent cell adhesion to vitronectin, vWf, fibrinogen, and thrombospondin. The CD61 antigen is found on all normal resting and activated platelets. The CD61 antigen is also found on endothelial cells, megakaryocytes, on some myeloid, erythroid and T-lymphoid leukemic cell lines.
Specifications

Specifications

CD61
Monoclonal
FITC
ITGB3
Liquid
ITGB3
purified platelet membrane glycoproteins
Protein A/G
RUO
Antibody
Monoclonal
Human
Flow Cytometry
43.PL
PBS with 0.2% carrier protein and 0.08% sodium azide
P05106
BDPLT2, CD61, GP3A, GPIIIa, GT, integrin beta-3, platelet glycoprotein IIIa, platelet membrane glycoprotein IIIa, ITGB3
Mouse
IgG1
100 Tests
4° C, do not freeze
Primary
3690
Documents
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