Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

CD61 Mouse anti-Human, PE, Clone: 43.PL, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112149

Catalog No. 01-670-868


Add to cart

Description

Description

Integrin beta3, also known as CD61, is a 130kDa transmembrane glycoprotein that binds noncovalently in complexes with integrin alpha subunits to form the functional receptor that binds to specific extracellular matrix proteins (e.g., fibronectin, vitronectin, etc.). Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrin receptors on the cell surface and their binding to the extracellular matrix leads to the formation of focal contacts and the activation of various signal transduction pathways. Phosphorylation of tyrosine 773 on Integrin beta3 activates the receptor and promotes cell adhesion. Tyr773 is commonly referred to as Tyr747, the corresponding site in the chicken Integrin beta3 protein.

Specifications

Specifications

CD61
Monoclonal
PE
ITGB3
Liquid
ITGB3
purified platelet membrane glycoproteins
Protein A/G
RUO
Antibody
Monoclonal
Human
Flow Cytometry
43.PL
PBS with 0.2% carrier protein and 0.08% sodium azide
P05106
BDPLT2, CD61, GP3A, GPIIIa, GT, integrin beta-3, platelet glycoprotein IIIa, platelet membrane glycoprotein IIIa, ITGB3
Mouse
IgG1
100 Tests
4° C, do not freeze
Primary
3690
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit