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ITGB5 Rabbit anti-Human, Polyclonal, Invitrogen™

Catalog No. 01673599
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7 mL
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Catalog No. Quantity
01-673-599 7 mL
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Catalog No. 01-673-599 Supplier Thermo Scientific Supplier No. PA137931

Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with hamster, mouse, and rat based on sequence homology. Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 10 min at room temperature. A suggested positive control is small intestine, bone marrow or colon carcinoma.

Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell-surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in-groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N-terminal extracellular domain that binds the ECM ligand and a small C-terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ITGB5
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Conjugate Unconjugated
Gene ITGB5
Gene Accession No. P18084
Gene Alias CD61, GP3A, GPIIIa
Gene Symbols ITGB5
Host Species Rabbit
Immunogen Synthetic peptide from C-terminus of human integrin beta 5 subunit
Purification Method Antigen affinity chromatography
Quantity 7 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3693
Target Species Human
Content And Storage 4° C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG
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