Interferon alpha-2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521926
PA5-21926 targets Interferon alpha-2 in ICC, IF, IHC (P), and WB applications and shows reactivity with Human samples. For immunohistochemistry, antigen retrieval using heat mediated 10 mM citrate buffer (pH 6.0) or Tris-EDTA buffer (pH 8.0) is recommended. The PA5-21926 immunogen is synthetic peptide contain a sequence corresponding to a region within amino acids 125 and 188 of interferon alpha 2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
|Synthetic peptide containing a sequence corresponding to a region within amino acids 125 and 188 of interferon alpha 2|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|RP11-354P17.2, IFN-alphaA, IFNA, IFNA2B, INFA2, IFN-alpha-2, alpha-2a interferon, interferon alpha 2b, interferon alpha A, interferon alpha-2, leIF A|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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