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IP3 Receptor 1 Rabbit anti-Canine, Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1901

Catalog No. PA1901


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Description

Description

PA1-901 detects inositol 1,4,5-trisphosphate receptor type-I (IP3R-I) from canine, mouse and rat tissues. PA1-901 has been successfully used in Western blot, immunohistochemistry, immunofluoresence and immunoprecipitation procedures. By Western blot, this antibody detects an ~240 kDa protein representing IP3R-I from rat and mouse brain extract. Immunohistochemical staining of IP3R-I in rat cerebellum with PA1-901 results in staining of Purkinje cells. PA1-901 immunizing peptide corresponds to amino acid residues 1829-1848 from human IP3R-I. This sequence is completely conserved in human, mouse, and rat IP3R-I. PA1-901 immunizing peptide (Cat. No. PEP-019) is available for use in neutralization and control experiments.

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
Specifications

Specifications

IP3 Receptor 1
Polyclonal
Unconjugated
ITPR1
Liquid
ITPR1
Synthetic Peptide: N(1829) K K K D D E V D R D A P S R K K A K E(1848)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
1.3 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
Q14643, P11881, P29994
Inositol 1,4,5-Triphosphate Receptor Type-I, IP3R
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
16438, 25262, 3708, 476548
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