IP3 Receptor 1 Rabbit anti-Canine, Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1901
PA1-901 detects inositol 1,4,5-trisphosphate receptor type-I (IP3R-I) from canine, mouse and rat tissues. PA1-901 has been successfully used in Western blot, immunohistochemistry, immunofluoresence and immunoprecipitation procedures. By Western blot, this antibody detects an ~240 kDa protein representing IP3R-I from rat and mouse brain extract. Immunohistochemical staining of IP3R-I in rat cerebellum with PA1-901 results in staining of Purkinje cells. PA1-901 immunizing peptide corresponds to amino acid residues 1829-1848 from human IP3R-I. This sequence is completely conserved in human, mouse, and rat IP3R-I. PA1-901 immunizing peptide (Cat. No. PEP-019) is available for use in neutralization and control experiments.Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
|IP3 Receptor 1|
|Synthetic Peptide: N(1829) K K K D D E V D R D A P S R K K A K E(1848)|
|Antigen affinity chromatography|
|Canine, Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|Q14643, P11881, P29994|
|Inositol 1,4,5-Triphosphate Receptor Type-I, IP3R|
|-20° C, Avoid Freeze/Thaw Cycles|
|16438, 25262, 3708, 476548|
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