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IP3 Receptor 1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA3901A

Catalog No. 01-670-201


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Description

Description

PA3-901A detects inositol 1,4,5-triphosphate receptor type-I (IP3R-I) from mouse, human and rat tissues. PA3-901A has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~240-260 kDa protein representing IP3R-I from rat and mouse brain extract. PA3-901A is a remanufactured lot of PA3-901 which has previously been used in Western blot, immunoprecipitation and immunohistochemistry procedures. The PA3-901A immunogen is a synthetic peptide corresponding to residues N(1829) K K K D D E V D R D A P S R K K A K E(1848) of human IP3 Receptor Type I. This sequence is 100% conserved in human, mouse, and rat IP3R-I protein. This peptide (Cat. No. PEP-019) is available for use in neutralization and control experiments.

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
Specifications

Specifications

IP3 Receptor 1
Polyclonal
whole serum diluted in PBS with 0.05% sodium azide
Q14643, P11881, P29994
Inositol 1,4,5,-Triphosphate Receptor Type I, IP3R
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
Unconjugated
ITPR1
Liquid
ITPR1
Synthetic peptide corresponding to residues N(1829) K K K D D E V D R D A P S R K K A K E(1848) of human IP3 Receptor Type I.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
16438, 25262, 3708
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