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Importin 9 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA525477

Catalog No. PIPA525477


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Description

Description

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of H2B histone, RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones, RPL4 and RPL6.
Specifications

Specifications

Importin 9
Polyclonal
PBS with 0.09% sodium azide
Q96P70, Q91YE6
Imp9, importin-9, ran-binding protein 9, ranBP9
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
226432, 55705
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
IPO9
Liquid
IPO9
KLH conjugated synthetic peptide between 79-106 amino acids from the N-terminal region of human IPO9
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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