IRAK-M Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA519969
In Western blot applications, this antibody detects a band at ~68kDa. A suggested positive control is mouse spleen tissue lysate. PA5-19969 can be used with blocking peptide PEP-0094.Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the domit negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.
|A peptide corresponding to 16 amino acids from the carboxy terminus of human IRAK-M.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|ASRT5, IRAKM; IL-1 receptor-associated kinase M|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|11213, 314870, 73914|
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