IRAK1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA130672
PA1-30672 detects IRAK from human samples. PA1-30672 has been successfully used in immunoprecipitation, Western blot applications. The PA1-30672 immunogen is: Peptide: C-terminus of human IRAK Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.Interleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. IRAK is associated with Toll-like receptor (TLR) and IL-1R signaling pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK ft.s association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
|Peptide: C-terminus of human IRAK|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|PBS with no preservative; pH 7.2|
|IL-1 Receceptor Associated Kinase, Interleukin-1 receptor-associated kinase 1, mPLK|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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