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IRAK1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141224

Catalog No. 01-675-778


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Description

Description

Suggested positive control: HeLa or NIH-3T3 whole cell lysate.

Interleukin-1 receptor-associated kinase 1 (IRAK1) is a serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. IRAK is associated with Toll-like receptor (TLR) and IL-1R signaling pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK ft.s association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
Specifications

Specifications

IRAK1
Polyclonal
Unconjugated
IRAK1
Liquid
IRAK1
Synthetic peptide corresponding to residues 700-712 of human IRaK.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunoprecipitation, Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
P51617, Q62406
IRAK, pelle
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
16179, 363520, 3654
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