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IRAK4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141054

Catalog No. 01-676-652


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Description

Description

Suggested positive control: antigen standard for IRAK4 (transient overexpression lysate), NIH-3T3 whole cell lysate.

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). IL-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members (2). The cytoplasmic domains of TIR proteins interact with the adapter protein, MyD88. MyD88 then recruits IRAKs (IRAK-1, -2, and M), which in turn interact with other adapter molecules, such as TRAF6 to activate NF-kB and MAPK pathways. Recently, a new member of this family, IRAK-4 has been identified (3). IRAK-4 may act as an upstream activator of IRAK-1. IRAK-4 is important for LPS activation of TLRS. Mice lacking IRAK-4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges (4, 5).
Specifications

Specifications

IRAK4
Polyclonal
Unconjugated
IRAK4
Liquid
IRAK4
Synthetic peptides corresponding to residues 38-54 and 120-136 of mouse IRaK-4.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Flow Cytometry, Immunoprecipitation, Western Blot
0.5 mg/mL
PBS with 0.05% sodium azide
Q9NWZ3, Q8R4K2
IPD1, NY-REN-64, REN64
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
266632, 300177, 51135
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