IRAK4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA141054
Suggested positive control: antigen standard for IRAK4 (transient overexpression lysate), NIH-3T3 whole cell lysate.The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). IL-1 receptor-associated kinases (IRAKs) are important mediators in the signal transduction of Toll/IL-1 receptor (TIR) family members (2). The cytoplasmic domains of TIR proteins interact with the adapter protein, MyD88. MyD88 then recruits IRAKs (IRAK-1, -2, and M), which in turn interact with other adapter molecules, such as TRAF6 to activate NF-kB and MAPK pathways. Recently, a new member of this family, IRAK-4 has been identified (3). IRAK-4 may act as an upstream activator of IRAK-1. IRAK-4 is important for LPS activation of TLRS. Mice lacking IRAK-4 are resistant to lethal doses of LPS and are also severely impaired in their responses to viral and bacterial challenges (4, 5).
|Synthetic peptides corresponding to residues 38-54 and 120-136 of mouse IRaK-4.|
|Human, Mouse, Rat|
|Flow Cytometry, Immunoprecipitation, Western Blot|
|PBS with 0.05% sodium azide|
|IPD1, NY-REN-64, REN64|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|266632, 300177, 51135|
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