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IRE1 alpha Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA146027

Catalog No. PA146027


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Description

Description

IRE1 alpha is the endoplasmic reticulum to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. IRE1 alpha protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. Specifically, IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator. Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER. Depletion of IRE1p through the expression of a domit negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER.
Specifications

Specifications

IRE1 alpha
Polyclonal
Unconjugated
ERN1
Liquid
ERN1
Synthetic peptide corresponding to residues 200-300 of human IRE1 alpha.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
0.9 mg/mL
PBS with 30% glycerol and 0.1% sodium azide
O75460, Q9EQY0
Serine/threonine-protein kinase/endoribonuclease IRE1, Inositol-requiring protein 1, IRE1p, IRE1a, Ire1-alpha , ERN1, Endoplasmic reticulum-to-nucleus
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
2081, 78943
Documents
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