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IRF1 Mouse anti-Human, Unlabeled, Clone: 20, BD

Mouse Monoclonal Antibody

$213.00 - $431.00

Specifications

Antigen IRF1
Isotype IgG1
Immunogen Human IRF1 aa. 159-279
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB612046
View Documents Promotion Details
BD Biosciences
612046
50μg
Each for $213.00
Add to cart
 
BDB612047
View Documents Promotion Details
BD Biosciences
612047
150μg
Each for $431.00
Add to cart
 
Description

Description

Cytokine function is critical for both innate and adaptive immune responses. Interferon (IFN) signal transduction pathways involve a variety of transcription factors that bind specific DNA motifs called IFN-stimulated response elements (ISRE) and IFN γ-activated sequences (GAS). The IFN regulatory factor (IRF) family is a group of transcription factors that bind to these DNA motifs and regulate the activity of IFN-responsive genes. The IRF family is comprised of seven different proteins (IRF1 to IRF7) that have been identified due to their interaction with ISRE and GAS sequences. IRF1 functions in the activation of IFN-responsive genes during induction of histocompatibility antigens, and inhibition of cell proliferation. In addition, IRF1 may function as a tumor suppressor, since deletions in the IRF1 locus is associated with myelodysplasia and leukemias. IRF2 is thought to be a transcriptional repressor, while others like IRF3 and IRF4 may function as activators or repressors depending on the specific promoter. In lymphocytes, IRF4 is required for normal development and function. Thus, IRFs regulate the activity of IFN-responsive genes required for normal immune function.

Host Species: Mouse
Clone: 20
Isotype: IgG1
Species Reactivity : Human
Immunogen: Human IRF1 aa. 159-279

Western Blotting

Specifications

Specifications

IRF1
Human IRF1 aa. 159-279
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
20
250μg/mL
SDS
Product Certifications

For Research Use Only.

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