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IRF4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521144

Catalog No. PIPA521144


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Description

Description

A suggested positive control is Jurkat cell lysate. PA5-21144 can be used with blocking peptide PEP-1258.

Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Another member, IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF4 expression is tightly regulated in resting primary T cells and plays an essential role in the homeostasis and function of mature lymphocytes. IRF4 is induced by Toll-like receptor (TLR) activation and acts as a negative regulator of TLR signaling.
Specifications

Specifications

IRF4
Polyclonal
Unconjugated
IRF4
Liquid
IRF4
A 16 amino acid peptide near the carboxy terminus of human IRF4.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q15306, Q64287
LSIRF, MUM1; IRF-4; NF-EM5; lymphocyte-specific interferon regulatory factor; multiple myeloma oncogene 1
Rabbit
IgG
100 μg
4° C
Primary
16364, 291100, 3662
Documents
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