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IRF7 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112810

Catalog No. 01-675-802


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Description

Description

Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.

A suggested positive control for this product is spleen, thymus or peripheral blood leukocytes.
Specifications

Specifications

IRF7
Polyclonal
Unconjugated
IRF7
Liquid
IRF7
Peptide corresponding to 14 residues from near the C-terminus of human IRF7.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q92985, P70434
IRF-7H, IRF7A
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
293624, 3665, 54123
Documents
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