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IRF8 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA124478

Catalog No. PIPA124478


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Description

Description

PA1-24478 detects Interferon regulatory factor 8 (IRF8) in human samples. PA1-24478 has been successfully used in immunohistochemistry (paraffin) and Western Blot procedures. By Western blot, PA1-24478 is specific for the ~48 kDa Interferon regulatory factor 8 (IRF8) protein. The PA1-24478 immunogen corresponds to a synthetic peptide corresponding to a region of human IRF8. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

IRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. IRF8 plays a negative regulatory role in cells of the immune system. It is involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells. This leads to recognition of AICE sequence, an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of the genes. Mutations in the gene can result in immunodeficiencey 32A and 32B.
Specifications

Specifications

IRF8
Polyclonal
Unconjugated
IRF8
Liquid
IRF8
Synthetic peptide corresponding to a region of human IRF8.
Affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 2% sucrose and 0.09% sodium azide
Q02556
H-ICSBP, ICSBP, ICSBP1, IRF-8
Rabbit
IgG
50 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
3394
Documents
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