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IRGC Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520790

Catalog No. PIPA520790


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Description

Description

A suggested positive control is mouse brain tissue lysate. PA5-20790 can be used with blocking peptide PEP-0904.

Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.
Specifications

Specifications

IRGC
Polyclonal
Unconjugated
IRGC
Liquid
IRGC, IRGC1
a 12 amino acid peptide near the carboxy terminus of human IRGC.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q6NXR0, Q8C262, Q6AYF9
CINEMA, IRGC1, Iigp5, R30953_1; immunity-related GTPase cinema 1; immunity-related GTPase family, cinema 1; interferon inducible GTPase 5; interferon-inducible GTPase 5
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
210145, 308428, 56269
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