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JAB1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA125464

Catalog No. PIPA125464

Item Discontinued This item has been discontinued by the supplier and is no longer available. Please reach out to your sales representative.


Description

Description

PA1-25464 detects JAB1 from human samples. PA1-25464 is expected to cross react with mouse (100% conserved) and rat (100% conserved) due to sequence homology. PA1-25464 has been successfully used in immunoprecipitation, and Western blot procedures. The PA1-25464 immunogen is a synthetic peptide: SGSGMAQKTWELANNMQ with C-terminal added cysteine, conjugated to KLH, corresponding to amino acids 4-20 of Human JAB1. The corresponding sequence is identical in mouse and rat.

JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the ""Signalosome"", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

JAB1
Polyclonal
Unconjugated
Q92905, O35864
COPS5
Synthetic peptide: SGSGMAQKTWELANNMQ with C-terminal added cysteine, conjugated to KLH, corresponding to amino acids 4-20 of Human JAB1. The corresponding sequence is identical in mouse and rat.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
0.9 mg/mL
COPS5
CSN5, JAB1, MGC3149, MOV-34, SGN5
Rabbit
Antigen affinity chromatography
RUO
10987, 26754, 312916
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
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