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JBP1/Skb1Hs Mouse, Unlabeled, Clone: 32, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611539

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Catalog No. BDB611539

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

p21[Cdc42/Rac]-activated kinases (PAKs) bind and are activated by the small GTPases, Cdc42 and Rac. In yeast, the interaction of the PAK, Shk1, with Skb1 (Shk1 kinase binding protein 1) is important in the regulation of cell morphology and mitosis. Skb1Hs, the human homolog of Skb1, restores growth rates in yeast cells deficient for Skb1. Skb1Hs has also been identified as a 72kDa pICln-binding protein (IBP72). pICln is thought to be a cytosolic regulator of a swelling-induced chloride channel and interactions with Skb1Hs suggest a link with PAKs, which are involved in cytoskeletal rearrangement. An additional line of study has identified Skb1Hs as a Jak binding protein (JBP1) via its interactions with Jak1-3 and Tyk2. This study also identified Skb1Hs as a methyltransferase that interacts with multiple proteins which possibly serve as physiological targets. Skb1Hs is expressed in a wide range of tissues and is thought to form homodimeric or multimeric complexes. Thus, Skb1Hs (IBP72, JBP1) is a multifunctional protein that may participate in such diverse processes as transcriptional and translational regulation, cytoskeletal rearrangement, and any of a number of signaling pathways.

Host Species: Mouse
Clone: 32
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Skb1Hs aa. 423-624
Formula Weight [Chemical]: 72kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

JBP1/Skb1Hs
32
Unconjugated
Murine
IgG1
RUO
Primary
Canine, Human, Murine, Rat
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Human Skb1Hs aa. 423-624
150μg
Cell Biology
Monoclonal
Documents
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