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JIP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen 345200

Encompass

Catalog No. 34-520-0


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Description

Description

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Specifications

Specifications

JIP1
Polyclonal
Unconjugated
MAPK8IP1
Liquid
MAPK8IP1
Synthetic peptide derived from the N-terminal region of the human JIP1 protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
0.25 mg/mL
PBS with 0.1% sodium azide; pH 7.4
Q9R237, Q9UQF2, Q9WVI9
IB1, JIP-1, JIP1, PRKM8IP, C-Jun-amino-terminal kinase-interacting protein 1, IB-1, JNK MAP kinase scaffold protein 1, JNK-interacting protein 1, PRKM8 interacting protein, islet-brain 1
Rabbit
IgG
100 μg
-20°C
Primary
116457, 19099, 9479
SDS
Documents
Product Certifications
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