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JIP1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527224

Catalog No. PIPA527224


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Description

Description

PA5-27224 targets JIP-1 in IHC (P), and WB applications and shows reactivity with Human samples. The PA5-27224 immunogen is recombit fragment corresponding to a region within amino acids 112 and 510 of Human JIP-1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
Specifications

Specifications

JIP1
Polyclonal
Unconjugated
MAPK8IP1
Liquid
MAPK8IP1
Recombit fragment corresponding to a region within amino acids 112 and 510 of Human JIP-1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Q9UQF2
IB1, JIP-1, JIP1, PRKM8IP, C-Jun-amino-terminal kinase-interacting protein 1, IB-1, JNK MAP kinase scaffold protein 1, JNK-interacting protein 1, PRKM8 interacting protein, islet-brain 1
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
9479
Documents
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