JMJD1A Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520802
A suggested positive control is mouse liver tissue lysate. PA5-20802 can be used with blocking peptide PEP-0916.The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintece of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintece of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist.
|A 16 amino acid peptide from near the amino terminus of human JMJD1A.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q9Y4C1, Q6PCM1, Q63679|
|JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA; jmjC domain-containing histone demethylation protein 2A; jumonji C domain-containing histone demethylase 2A; jumonji domain containing 1; jumonji domain containing 1A; jumonji domain-containing protein 1A; lysine-specific demethylase 3A; testis-specific protein A|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|104263, 312440, 55818|
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