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JMJD1A Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520802

Catalog No. PIPA520802


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Description

Description

A suggested positive control is mouse liver tissue lysate. PA5-20802 can be used with blocking peptide PEP-0916.

The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. JMJD1A is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of STAT3, a protein that has been found to be important in the maintece of mouse embryonic stem (mES) cells, and decreased JMJD1A expression correlated with the differentiation of cultured mES cells following the removal of the cytokine LIF. These findings suggest that JMJD1A might be a critical signaling molecule underlying the maintece of pluripotency in embryonic stem cells. At least two isoforms of JMJD1A are known to exist.
Specifications

Specifications

JMJD1A
Polyclonal
Unconjugated
KDM3A
Liquid
KDM3A
A 16 amino acid peptide from near the amino terminus of human JMJD1A.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9Y4C1, Q6PCM1, Q63679
JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA; jmjC domain-containing histone demethylation protein 2A; jumonji C domain-containing histone demethylase 2A; jumonji domain containing 1; jumonji domain containing 1A; jumonji domain-containing protein 1A; lysine-specific demethylase 3A; testis-specific protein A
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
104263, 312440, 55818
Documents
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