JMJD2A Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520806
A suggested positive control is rat liver tissue lysate. PA5-20806 can be used with blocking peptide PEP-0920.Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. The first member of this group, JMJD2A, is widely expressed in human tissues and cell lines and functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. JMJD2A can also form a complex with the androgen receptor (AR), a transcription factor that is pivotal for the development of prostate cancer. Overexpression of JMJD2A stimulates AR function and this stimulation is dependent on JMJD2A catalytic activity, suggesting that JMJD2A might be a critical protein with roles in cell proliferation and oncogenesis.
|A 14 amino acid peptide from near the center of human JMJD2A.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|JHDM3A, JMJD2, JMJD2A; jmjC domain-containing histone demethylation protein 3A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; jumonji domain-containing protein 2A; lysine-specific demethylase 4A|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|230674, 313539, 9682|
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