JMJD2D Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA511148
DescriptionCovalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
|PBS with 0.09% sodium azide|
|Jumonji domain containing 2D; JMJD2D;; KDM4D|
|-20° C, Avoid Freeze/Thaw Cycles|
|KLH conjugated synthetic peptide between 484-516 amino acids from the C-terminal region of human JMJD2D|
|Ammonium sulfate precipitation, Size-exclusion - Dialysis|
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