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JMJD2D Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA511148

Catalog No. PIPA511148


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Description

Description

Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Specifications

Specifications

JMJD2D
Polyclonal
PBS with 0.09% sodium azide
Q6B0I6
Jumonji domain containing 2D; JMJD2D;; KDM4D
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
55693
Western Blot
Unconjugated
KDM4D
Liquid
KDM4D
KLH conjugated synthetic peptide between 484-516 amino acids from the C-terminal region of human JMJD2D
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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