JunD Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1834
PA1-834 detects JunD from mouse cells. PA1-834 has been successfully used in Western blot and ChIP procedures. By Western blot, this antibody detects proteins from ~37-41 kDa representing JunD from both un-induced and induced mouse NIH 3T3 cells. The PA1-834 immunogen is a synthetic peptide corresponding to residues G(329) C Q L L P Q H Q V P A Y(341) of mouse JunD. This sequence is comletely conserved between mouse, human and rat. Reconstitute with PBS.Cellular oncogenes, or proto-oncogenes, play pivotal roles in cellular communication pathways that regulate normal growth, development and differentiation. The cellular oncogene families fos and jun encode nuclear proteins that can function as transcription factors. The fos family of nuclear oncogenes encode cFos, FosB, (fos-related antigen) Fra1, and Fra2. Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ‘leucine-zipper’ motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.
|Synthetic peptide corresponding to residues G(329) C Q L L P Q H Q V P A Y(341) of mouse JunD.|
|ChIP assay, Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.05% sodium azide|
|-20° C, Avoid Freeze/Thaw Cycles|
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