CD82 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520356
A suggested positive control is A549 cell lysate. PA5-20356 can be used with blocking peptide PEP-0476.KAI1 was initially identified from a T-cell activation study as a four-transmembrane protein that plays an accessory role in T-cell activation, and was later determined to act as a cancer metastasis suppressor gene. This protein is ubiquitously expressed at moderate to high levels in most tissues, but its expression is downregulated during tumor progression. The loss of KAI1 and p53 is associated with poor survival for prostate and other cancer patients. Recently, KAI1 was found to interact with DARC, the Duffy antigen for chemokines using a yeast two hybrid screen. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least two isoforms of KAI1 are known to exist.
|A 15 amino acid peptide from near the carboxy terminus of human KAI1.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|P27701, P40237, O70352|
|4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27, C33 antigen, CD82 antigen, inducible membrane protein R2|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|12521, 3732, 83628|
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