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Prekallikrein Mouse anti-Human, Clone: 13G11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA126321

Catalog No. MA126321


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Description

Description

MA1-26321 detects Prekallikrein / Kallikrein from human samples. MA1-26321 has been successfully used in inhibition assay, ELISA and Western blot procedures. The MA1-26321 immunogen is purified human prekallikrein. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
Specifications

Specifications

Prekallikrein
Monoclonal
0.61 mg/mL
PBS with no preservative; pH 7.2
P03952
KLKB1
Purified human prekallikrein.
Protein G
RUO
Antibody
Monoclonal
Human
ELISA, Inhibition Assays, Western Blot
13G11
Unconjugated
KLKB1
Liquid
Mouse
IgG1
50 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
3818
SDS
Documents
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