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KappaB ras1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520341

Catalog No. PIPA520341


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Description

Description

A suggested positive control is RAW264.7 cell lysate. PA5-20341 can be used with blocking peptide PEP-0461.

KappaB ras-1 (kappa-B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with Ikappa-B (Ikappa-B), an inhibitor of the transcription factor NF-kappa-B. Ikappa-B exists in two homologous forms, Ikappa-B-alpha and Ikappa-B-beta, although Ikappa-B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive Ikappa-B-alpha-NF-kappa-B complexes can shuttle in and out of the nucleus, Ikappa-B-beta-NF-kappa-B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the Ikappa-B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Ikappa-B-beta and regulating the rate of degradation of Ikappa-B-beta. This antibody is specific for kappaB-ras1 and has no cross-reactivity to kappaB-ras2.
Specifications

Specifications

KappaB ras1
Polyclonal
PBS with 0.02% sodium azide
Q9NYS0, Q8CEC5
KBRAS1, kappaB-Ras1; I-kappa-B-interacting Ras-like protein 1; NF-kappa-B inhibitor-interacting Ras-like protein 1; NFKB inhibitor interacting Ras-like protein 1; kappa B-Ras protein 1; kappa B-ras 1
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
28512, 69721
Immunocytochemistry, Western Blot
Unconjugated
NKIRAS1
Liquid
NKIRAS1
A 15 amino acid peptide from near the carboxy terminus of human KappaB ras1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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