KappaB ras1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520341
A suggested positive control is RAW264.7 cell lysate. PA5-20341 can be used with blocking peptide PEP-0461.KappaB ras-1 (kappa-B-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with Ikappa-B (Ikappa-B), an inhibitor of the transcription factor NF-kappa-B. Ikappa-B exists in two homologous forms, Ikappa-B-alpha and Ikappa-B-beta, although Ikappa-B-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive Ikappa-B-alpha-NF-kappa-B complexes can shuttle in and out of the nucleus, Ikappa-B-beta-NF-kappa-B complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the Ikappa-B-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of Ikappa-B-beta and regulating the rate of degradation of Ikappa-B-beta. This antibody is specific for kappaB-ras1 and has no cross-reactivity to kappaB-ras2.
|PBS with 0.02% sodium azide|
|KBRAS1, kappaB-Ras1; I-kappa-B-interacting Ras-like protein 1; NF-kappa-B inhibitor-interacting Ras-like protein 1; NFKB inhibitor interacting Ras-like protein 1; kappa B-Ras protein 1; kappa B-ras 1|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Immunocytochemistry, Western Blot|
|A 15 amino acid peptide from near the carboxy terminus of human KappaB ras1.|
|Antigen affinity chromatography|
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