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Karyopherin β Mouse, Unlabeled, Clone: 23, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 610559

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Catalog No. BDB610559

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Using nuclear import assays, several cytosolic proteins that form a multi-protein complex have been identified. These proteins of 54kDa, 56kDa, and 97kDa stimulate the nuclear transport of proteins containing a nuclear localization signal (NLS). The 97kDa protein has been named karyopherin β. The NLS binds to karyopherin α. Binding is enhanced by karyopherin β. The NLS substrate also binds to the N-terminal region of karyopherin β. Both karyopherins bind to repeat sequences of nucleoporins at the nuclear envelope. Once the substrate is docked to the nuclear envelope, Ran hydrolyzes GTP and translocation occurs. Karyopherin β also binds to and inhibits the Ran GTPase protein, thus providing a mechanism of nuclear transport termination.

Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting



Karyopherin β
Affinity Purified
Rat Karyopherin β aa. 48-241
Cell Biology
Canine, Human, Murine, Rat
Western Blot
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Store undiluted at -20°C.
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