Karyopherin β Mouse, Unlabeled, Clone: 23, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 610559
Using nuclear import assays, several cytosolic proteins that form a multi-protein complex have been identified. These proteins of 54kDa, 56kDa, and 97kDa stimulate the nuclear transport of proteins containing a nuclear localization signal (NLS). The 97kDa protein has been named karyopherin β. The NLS binds to karyopherin α. Binding is enhanced by karyopherin β. The NLS substrate also binds to the N-terminal region of karyopherin β. Both karyopherins bind to repeat sequences of nucleoporins at the nuclear envelope. Once the substrate is docked to the nuclear envelope, Ran hydrolyzes GTP and translocation occurs. Karyopherin β also binds to and inhibits the Ran GTPase protein, thus providing a mechanism of nuclear transport termination.
Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
|Rat Karyopherin β aa. 48-241|
|Canine, Human, Murine, Rat|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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