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KappaB ras1 Mouse anti-Bovine, Canine, Equine, Human, Mouse, Non-human primate, Porcine, Rat, Xenopus laevis, Clone: 184C278, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141180

Catalog No. 01-676-586


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Description

Description

Suggested positive control: 293 whole cell lysate.

NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB (1). Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-6). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified (1). One of the first genes induced following NF-kB activation is IkBa. Recently, two proteins, kB-Ras1 and kB-Ras2 have been identified (7). These two proteins interact with PEST domains of IkBa and IkBb and decrease their rate of degradation.
Specifications

Specifications

KappaB ras1
Monoclonal
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
Q9NYS0, Q8CEC5
C15orf1, I1PP2A, LANP, MAPM, MGC119787, MGC150373, PHAP1, PHAPI, PP32
Mouse
IgG1
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100036787, 100051752, 100620195, 28512, 305751, 477047, 522875, 69721
Western Blot
184C278
Unconjugated
NKIRAS1
Liquid
NKIRAS1, nkiras1.S
Synthetic peptide corresponding to residues 96-113 of human kB-Ras1.
Protein G
RUO
Antibody
Monoclonal
Bovine, Canine, Equine, Human, Mouse, Non-human primate, Porcine, Rat, Xenopus laevis
Documents
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