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KCNQ2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1929

Catalog No. PA1929


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Description

Description

PA1-929 detects KCNQ2 from mouse, human and rat samples. This antibody is specific for KCNQ2 and does not detect KCNQ1, KCNQ3, KCNQ4 or KCNQ5. PA1-929 has been successfully used in Western blot, immunofluorescence, immunohistochemistry and immunocytochemistry procedures. Immunohistochemical staining of rat hippocampal using PA1-929 yielded a strong signal in granule cell layer and the mossy fibers found in the central hilus of the dentate gyrus. PA1-929 immunogen is a GST fusion protein encoding the first 70 amino acids of human KCNQ2.

KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system and KNCQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
Specifications

Specifications

KCNQ2
Polyclonal
Unconjugated
KCNQ2
Liquid
KCNQ2
GST fusion protein encoding the first 70 amino acids of human KCNQ2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.02% sodium azide
O43526, Q9Z351, O88943
BFNC, EBN1, ENB1, HNSPC, KCNA11, KQT like 2, KVEBN1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
16536, 170848, 3785
Documents
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