KCNQ3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1930
PA1-930 detects KCNQ3 from mouse, human and rat samples. This antibody is specific for KCNQ3 and does not detect KCNQ1, KCNQ2, KCNQ4 or KCNQ5. PA1-930 has been successfully used in immunofluorescence, immunohistochemistry and immunocytochemistry procedures. Immunohistochemical staining using PA1-930 yielded a strong signal mainly in interneurons and astrocytes in the dentate region of rat hippocampal samples. PA1-930 immunogen is a GST fusion protein encoding the first 71 amino acids of rat KCNQ3.KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KCNQs (KCNQ1-5) found in the central nervous system and KCNQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
|GST fusion protein encoding the first 71 amino acids of rat KCNQ3.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen)|
|PBS with 1mg/mL BSA and 0.02% sodium azide|
|O43525, Q8K3F6, O88944|
|BFNC, BFNC2, EBN2, Voltage-gated potassium channel subunit Kv7.3|
|-20° C, Avoid Freeze/Thaw Cycles|
|110862, 29682, 3786|
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