KEAP1 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528368
PA5-28368 targets KEAP1 in WB applications and shows reactivity with Human samples. The PA5-28368 immunogen is recombit fragment corresponding to a region within amino acids 387 and 619 of Human KEAP1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
|Recombit fragment corresponding to a region within amino acids 387 and 619 of Human KEAP1|
|Antigen affinity chromatography|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|INrf2, KLHL19, cytosolic inhibitor of Nrf2, kelch-like protein 19|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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