Cytokeratin 14 Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA138001
Staining of formalin-fixed tissues requires digesting tissue sections with Pepsin for 10 min at 37°C, followed by incubation with primary antibody for 10 min at room temperature. A suggested positive control is skin or squamous cell carcinoma.Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. skin) and non-keratinizing cells (ie. mesothelial cells). At least 20 different CKs can be identified. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). Belonging to the type I subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells.
|PBS with 1% BSA and 0.1% sodium azide; pH 7.6|
|CK14, EBS3, EBS4, K14, NFJ, CK-14, cytokeratin 14, cytokeratin-14, keratin 14 epidermolysis bullosa simplex, Dowling-Meara, Koebner, keratin, type I cytoskeletal 14, keratin-14|
|Synthetic peptide derived from C-terminus of human Keratin 14|
|Antigen affinity chromatography|
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