Cytokeratin 5 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA137974
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is skin, breast, prostate or mesothelioma.Twenty human keratins are divided into acidic (pI <5.7) and basic (pI >6.0) subfamilies. Members of the acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor identification. Point mutations in cytokeratin5 gene can cause various types of epidermolysis bullosa simplex. It is expressed in most epithelial and biphasic mesotheliomas.
|PBS with 1% BSA and <0.1% sodium azide; pH 7.6|
|CK5, DDD, EBS2, K5, KRT5A, 58 kda cytokeratin, CK-5, cytokeratin-5, epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types, keratin 5 epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types, keratin, type II cytoskeletal 5, type-II keratin Kb5|
|4° C, do not freeze|
|Synthetic peptide corresponding to C-terminus of human cytokeratin 5.|
|Antigen affinity chromatography|
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