Kindlin 3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520598
A suggested positive control is rat spleen tissue lysate. PA5-20598 can be used with blocking peptide PEP-0718.The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.
|A 19 amino acid peptide near the carboxy terminus of the human KINDLIN3.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|PBS with 0.02% sodium azide|
|KIND3, MIG-2, MIG2B, UNC112C, URP2, URP2SF; MIG2-like protein; UNC-112 related protein 2; fermitin family homolog 3; kindlin 3; unc-112-related protein 2|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|108101, 309186, 83706|
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