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Kindlin 3 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520598

Catalog No. PIPA520598


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Description

Description

A suggested positive control is rat spleen tissue lysate. PA5-20598 can be used with blocking peptide PEP-0718.

The three KINDLINs are a novel family of focal adhesion proteins, localizing to integrin adhesion sites. The KINDLIN proteins are composed of a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain. KINDLIN1 and KINDLIN2 have been shown to play an essential role in integrin-mediated adhesion and spreading. In contrast to the widely expressed KINDLIN1 and KINDLIN2, KINDLIN3 is restricted to hematopoietic cells and is particularly abundant in megakaryocytes and platelets. Several reports describe a transcriptional misregulation of KINDLINs in various types of cancer. A recent study demonstrates that KINDLIN3 is essential for platelet integrin activation and subsequent integrin outside-in signaling, suggesting it may serve as a potential target for the design of therapeutics aimed at specifically disrupting integrin activation in platelets and leukocytes.
Specifications

Specifications

Kindlin 3
Polyclonal
Unconjugated
FERMT3
Liquid
FERMT3
A 19 amino acid peptide near the carboxy terminus of the human KINDLIN3.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q86UX7, Q8K1B8
KIND3, MIG-2, MIG2B, UNC112C, URP2, URP2SF; MIG2-like protein; UNC-112 related protein 2; fermitin family homolog 3; kindlin 3; unc-112-related protein 2
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
108101, 309186, 83706
Documents
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