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Kininogen 1 Rat anti-Mouse, Clone: 288422, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523988

Catalog No. PIMA523988


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Description

Description

In Western blots, reacts with the full length mouse Kininogen (aa 21-661), but not with the light chain alone. In Western blots, no cross-reactivity with recombit human (rh) Cystatin D, F, SA, SN, recombit mouse (rm) Cystatin A, B, C, E/M, rmCystatin/Stefin Homolog, rmFetuin A, rhFetuin B, rmHPRG, rhKininogen, or rhKininostatin is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

Kininogen 1
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
O08677
BDK, KNG, HMWK, alpha-2-thiol proteinase inhibitor, bradykinin, fitzgerald factor, high molecular weight kininogen, kininogen-1, williams-Fitzgerald-Flaujeac factor
Rat
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
16644
Immunoprecipitation, Western Blot
288422
Unconjugated
Kng1
Lyophilized
KNG1
Mouse myeloma cell line NS0-derived recombit mouse Kininogen Glu21-Ser661
Protein A/G
RUO
Antibody
Monoclonal
Mouse
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