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Kininogen Light Chain Rat anti-Mouse, Clone: 288424, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA523989

Catalog No. PIMA523989


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Description

Description

In Western blots, reacts with full length Kininogen (aa 21-661) and several forms of the light chain starting at residue 389, and does not react with the heavy chain. In Western blots, no cross-reactivity with recombit mouse (rm) Cystatin A, B, C, E/M, recombit human (rh) Cystatin D, F, S, SA, SN, rmCystatin/Stefin Homolog, rmFetuin A, rhFetuin B, rmHPRG, rhKininogen, or rhKininostatin is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

Kininogen Light Chain
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
O08677
BDK, KNG, HMWK, alpha-2-thiol proteinase inhibitor, bradykinin, fitzgerald factor, high molecular weight kininogen, kininogen-1, williams-Fitzgerald-Flaujeac factor
Rat
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
16644
Immunoprecipitation, Western Blot
288424
Unconjugated
Kng1
Lyophilized
KNG1
Mouse myeloma cell line NS0-derived recombit mouse Kininogen Glu21-Ser661
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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