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KIR2DL4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA528190

Catalog No. PIPA528190


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Description

Description

PA5-28190 targets KIR2DL4 in IHC (P) and WB applications and shows reactivity with Human samples. The PA5-28190 immunogen is recombit fragment corresponding to a region within amino acids 1 and 254 of Human KIR2DL4. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants.
Specifications

Specifications

KIR2DL4
Polyclonal
Unconjugated
KIR2DL4
Liquid
KIR2DL4
Recombit fragment corresponding to a region within amino acids 1 and 254 of Human KIR2DL4
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
0.9 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Q99706
CD158D, G9P, KIR103, KIR103AS, CD158 antigen-like family member D, KIR-103AS, MHC class I NK cell receptor KIR103AS, NK cell receptor, killer Ig receptor, killer cell immunoglobulin-like receptor 2DL4, killer cell inhibitory receptor 103AS, natural killer cell inhibitory receptor
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
3805
Documents
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