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KIR2DS2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA525668

Catalog No. PIPA525668

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several  ft.framework ft. genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
Specifications

Specifications

KIR2DS2
Polyclonal
Unconjugated
KIR2DS2
Liquid
KIR2DS2
KLH conjugated synthetic peptide between 39-65 amino acids from the central region of human KIR2DS2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
P43631
183ActI, CD158J, CD158b, NKAT5, cl-49, 1060P11.9.2, CD158 antigen-like family member J, MHC class I NK cell receptor, NK receptor 183 ActI, NKAT-5, killer cell immunoglobulin-like receptor 2DS2, killer-cell Ig-like receptor, killer-cell immunoglobulin-like receptor two domains short tail 2 protein, na
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
100132285
Documents
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