KLF4 Goat anti-Human, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA518058
This antibody is predicted to react with bovine, mouse and rat based on sequence homology.KLF4 (Kruppel-like factor 4 (gut)) is a transcription factor that can act both as an activator and as a repressor. KLF4 binds to the 5 ft.-CACCC-3 ft. core sequence, and binds to the promoter region of its own gene and it can activate its own transcription. It regulates the expression of key transcription factors during embryonic development. KLF4 plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. It is required for establishing the barrier function of the skin and for postnatal maturation and maintece of the ocular surface. It is also involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Diseases associated with KLF4 include skin sequamous cell carcinoma and familial adenomatous polyposis.
|Synthetic peptide sequence (AVSDALLPSFST) corresponding to the N-terminus amino acids of KLF4|
|Antigen affinity chromatography|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|KLF4; GKLF; Kruppel-like factor 4 (gut); EZF; endothelial Kruppel-like zinc finger protein|
|-20° C, Avoid Freeze/Thaw Cycles|
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