KLRG1 Hamster anti-Mouse, Brilliant Violet 421, Clone: 2F1, BD
Hamster Monoclonal Antibody
Manufacturer: BD Biosciences 562897
The 2F1 monoclonal antibody specifically binds to KLRG1 (Killer cell Lectin-like Receptor mmunoreceptor Tyrosine-based Inhibitory Motif);its ligand has not beenidentified KLRG1 is expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kDa. The level of KLRG1 expression is reduced in MHC class I-deficient mice, although direct binding of KLRG1 to MHC class I antigens could not be detected. Cross-linking of KLRG1 by 2F1 mAb reduces TCR-mediated Ca++mobilization and cytotoxic responses (but not IFN-γ production) by CD8+ T cellsand inhibits IFN-γ and TNF-αproduction and redirected lysis by NK cells.
|Brilliant Violet 421|
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|Klrg1; Killer cell lectin-like receptor subfamily G member 1; MAFA|
|A-LAK from C57BL/6 mice|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok