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KLRG1 Rat anti-Mouse, PerCP-Cy5.5, Clone: 2F1, BD

Rat Monoclonal Antibody

Manufacturer:  BD Biosciences 563595

Catalog No. BDB563595


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Description

Description

The 2F1 monoclonal antibody specifically binds to KLRG1 (Killer cell Lectin-like Receptor mmunoreceptor Tyrosine-based Inhibitory Motif);its ligand has not beenidentified KLRG1 is expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kDa. The level of KLRG1 expression is reduced in MHC class I-deficient mice, although direct binding of KLRG1 to MHC class I antigens could not be detected. Cross-linking of KLRG1 by 2F1 mAb reduces TCR-mediated Ca++mobilization and cytotoxic responses (but not IFN-γ production) by CD8+ T cellsand inhibits IFN-γ and TNF-αproduction and redirected lysis by NK cells.

Specifications

Specifications

KLRG1
2F1
PerCP-Cyanine5.5
Aqueous buffered solution containing ≤0.09% sodium azide.
Rat
IgG2, κ
RUO
Primary
Murine
Flow Cytometry
0.2mg/mL
Klrg1; Killer cell lectin-like receptor subfamily G member 1; MAFA
Affinity Purified
A-LAK from C57BL/6 mice
50μg
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Monoclonal
Documents
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