KLRG1 Rat anti-Mouse, PerCP-Cy5.5, Clone: 2F1, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 563595
The 2F1 monoclonal antibody specifically binds to KLRG1 (Killer cell Lectin-like Receptor mmunoreceptor Tyrosine-based Inhibitory Motif);its ligand has not beenidentified KLRG1 is expressed mainly as a homodimeric molecule consisting of two N-glycosylated subunits of approximately 30-38 kDa. The level of KLRG1 expression is reduced in MHC class I-deficient mice, although direct binding of KLRG1 to MHC class I antigens could not be detected. Cross-linking of KLRG1 by 2F1 mAb reduces TCR-mediated Ca++mobilization and cytotoxic responses (but not IFN-γ production) by CD8+ T cellsand inhibits IFN-γ and TNF-αproduction and redirected lysis by NK cells.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|Klrg1; Killer cell lectin-like receptor subfamily G member 1; MAFA|
|A-LAK from C57BL/6 mice|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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