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TNK1 Rabbit anti-Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA14332

Catalog No. PA14332


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Description

Description

PA1-4332 detects Kos1 (a.k.a. TNK1) from mouse samples. PA1-4332 has been successfully used in Western blot procedures. PA1-4332 immunizing peptide corresponds to amino acid residues 421-434 from mouse Kos1 Protein.

Kinase of embryonic stem cells (Kos1) is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Kos1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Kos1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
Specifications

Specifications

TNK1
Polyclonal
Unconjugated
Tnk1
Liquid
TNK1
Synthetic Peptide: Q(421) N Q V Q S L P A G S A E P(434)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Mouse
Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q99ML2
Non-receptor tyrosine-protein kinase TNK1, Kinase of embryonic stem cells
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
83813
Documents
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