TNK1 Rabbit anti-Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA14332
PA1-4332 detects Kos1 (a.k.a. TNK1) from mouse samples. PA1-4332 has been successfully used in Western blot procedures. PA1-4332 immunizing peptide corresponds to amino acid residues 421-434 from mouse Kos1 Protein.Kinase of embryonic stem cells (Kos1) is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Kos1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Kos1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Kos1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
|Synthetic Peptide: Q(421) N Q V Q S L P A G S A E P(434)|
|Antigen affinity chromatography|
|PBS with 0.02% sodium azide|
|Non-receptor tyrosine-protein kinase TNK1, Kinase of embryonic stem cells|
|-20° C, Avoid Freeze/Thaw Cycles|
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