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KPNA1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521032

Catalog No. PIPA521032

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A suggested positive control is Hela cell lysate. PA5-21032 can be used with blocking peptide PEP-1146.

Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA1, also known as importin alpha 5, is the alpha subunit of karyopherin, which forms a complex with importin subunit beta-1 and functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. It is ubiquitously expressed and polyubiquitinated in the presence of RAG1. KPNA1 interacts with various virus nucleoproteins, including those of Ebola and influenza.


A 15 amino acid peptide near the amino terminus of human KPNA1.
Antigen affinity chromatography
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P52294, Q60960, P83953
IPOA5, NPI-1, RCH2, SRP1; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin subunit alpha-1; importin-alpha-S1; karyopherin subunit alpha-1; nucleoprotein interactor 1; recombination activating gene cohort 2
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
16646, 288064, 3836
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