KPNA6 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521036
A suggested positive control is 293 cell lysate. PA5-21036 can be used with blocking peptide PEP-1150.Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5&6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promote its nuclear import.
|A 13 amino acid peptide near the amino terminus of human KPNA6.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|RP4-622L5.1, IPOA7, KPNA7; importin alpha 7 subunit; importin subunit alpha-7; importin-alpha-S2; karyopherin subunit alpha-6|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|16650, 23633, 362607|
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