Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ anti-Kpnbeta1, Polyclonal

Rabbit Polyclonal Antibody

Manufacturer:  MilliporeSigma™ ST110250UG

Catalog No. ST110250UG

Add to cart



Specifically detects Kpnβ1 Clone: in Human, Mouse, Xenopus samples, and it is validated for Immunoprecipitation

Full-length Kpnβ1 (Accession,num; NP_002256) consists of 19 HEAT repeats that form a compact superhelical coil. While other members of the Kpnβ family bind their substrates directly, Kpnβ1 uses Kpnα as an adaptor for binding substrates that contain a classical NLS. However, Kpnβ1 can also import some substrates, such as HIV Rev, GAL4, T-cell tyrosine phosphatase, cyclin B1, and parathyroid hormone-related protein (PTHrP), without binding Kpnα. Kpnβ1 docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importinα enters the nucleoplasm with its passenger protein and importinβ remains at the pore. Interactions between Kpnβ1 and the FG repeats of nucleoporins are essential in translocation through the pore complex.


a synthetic peptide corresponding to amino acids near the C-terminus of human Kpnβ1
Human, Murine, Xenopus
In Tris-citrate/phosphate buffer, pH 7-8.
Recognizes the ∽97kDa Kpnβ1 protein in Jurkat cells.
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only