LDHA Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523036
This antibody is predicted to react with bovine and porcine based on 100% sequence homology.Lactate dehydrogenase (LDH) is an ubiquitous enzyme commonly found in a wide variety of organisms, including plants and microbes. LDH is involved in the interconversion of the pyruvate and NADH to lactate and NAD+. It is also called Hydroxybutyrate Dehydrogenase (HBD), due to the fact that it can catalyze the oxidation of hydroxybutyrate (1). In mammals, three types of LDH subunits (35 kDa) are encoded by the genes Ldh-A, Ldh-B, and Ldh-C, forming various terameric isoenzymes (140 kDa). Lactate dehydrogenase A (LDH-A, muscle subunit, LDH-M) is involved in the final step of anaerobic glycolysis and catalyzes the conversion of L-lactate and NAD to pryruvate and NADH. While it is predomitly expressed in muscle tissue, it is hormonally regulated in rodents and overexpressed during mammary gland tumorigenesis (2). A mutation that causes deficiency in LDH-A has been implicated in exertional myoglobinuria (3).
|Synthetic peptide made to an C-terminal portion of the human LDHA protein (within residues 280-332).|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)|
|PBS with 30% glycerol and 0.1% sodium azide|
|PIG19, GSD11, LDH1, LDHM, L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-A, LDH-M, cell proliferation-inducing gene 19 protein, lactate dehydrogenase M, proliferation-inducing gene 19, renal carcinoma antigen NY-REN-59|
|-20° C, Avoid Freeze/Thaw Cycles|
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