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LDHA Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523036

Catalog No. PIPA523036


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Description

Description

This antibody is predicted to react with bovine and porcine based on 100% sequence homology.

Lactate dehydrogenase (LDH) is an ubiquitous enzyme commonly found in a wide variety of organisms, including plants and microbes. LDH is involved in the interconversion of the pyruvate and NADH to lactate and NAD+. It is also called Hydroxybutyrate Dehydrogenase (HBD), due to the fact that it can catalyze the oxidation of hydroxybutyrate (1). In mammals, three types of LDH subunits (35 kDa) are encoded by the genes Ldh-A, Ldh-B, and Ldh-C, forming various terameric isoenzymes (140 kDa). Lactate dehydrogenase A (LDH-A, muscle subunit, LDH-M) is involved in the final step of anaerobic glycolysis and catalyzes the conversion of L-lactate and NAD to pryruvate and NADH. While it is predomitly expressed in muscle tissue, it is hormonally regulated in rodents and overexpressed during mammary gland tumorigenesis (2). A mutation that causes deficiency in LDH-A has been implicated in exertional myoglobinuria (3).
Specifications

Specifications

LDHA
Polyclonal
Unconjugated
LDHA
Liquid
LDHA
Synthetic peptide made to an C-terminal portion of the human LDHA protein (within residues 280-332).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)
1.25 mg/mL
PBS with 30% glycerol and 0.1% sodium azide
P00338, P06151
PIG19, GSD11, LDH1, LDHM, L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-A, LDH-M, cell proliferation-inducing gene 19 protein, lactate dehydrogenase M, proliferation-inducing gene 19, renal carcinoma antigen NY-REN-59
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
16828, 3939
Documents
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